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非洲猪瘟疫苗进展 包括AD域的Asn153和Leu211

发布时间 2019-05-29 21:46:08 阅读数: 26 作者:

2019年1月23日。揭示了AsfvDNAL结合和催化底物连接的分子机制,该研究用X射线晶体学方法解析了AsfvDNAL与不同类型DNA复合物的结构,为针对非洲猪瘟病毒DNA修复通路蛋白的药物设计提供了结构基础。复旦大学甘建华,李继喜及四川大学/佐治亚州立大学HuangZhen共同通讯等在NatureCommunications上发表题为"StructureoftheerrorproneDNAligaseofAfricanswinefevervirusidentifiescriticalactivesiteresidues"的。

报道了四个独特的活性位点残基对AsfvLIG的催化效率至关重要,1月23日。AsfvLIG包含四个独特的残基。这些残基可能与其相应的NTD或DBD结构域协同工作。包括AD域的Asn153和Leu211;这些位点残基对缺口的识别和催化效率有着重要的意义。该文章发现的4种独特的结构特征可以作为小分子设计的潜在靶点,这可能会损害ASFV的基因组。

并有助于今后对抗这种病毒,该项目得到了国家自然科学基金和中国重点研发项目。四川省重点研发项目资助。

非洲猪瘟疫苗进展

农业农村部,重点推进非洲猪瘟疫苗创制为切实做好当前非洲猪瘟防控工作!加强非洲猪瘟防控技术科研攻关,2019年1月25日;农业农村部办公厅关于进一步加强非洲猪瘟综合防控技术科研攻关的通知,通知要求重点推进非洲猪瘟疫苗。

积极开展技术合作,各级各类农业科研单位要充分利用相关高校,科研院所等单位的技术和硬件。

加快研发进程,联合开展技术。

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